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Gunasekera, Sarath
National Museum of Natural History staff
Positions
Selected Publications
Article
Monti, M., Giorgi, A., Paul, Valerie J., Gunasekera, Sarath P., Houk, L. Jay, Dugan, Carle, Demarco, Tommy, and Olson, J. B. 2024. "Natural products from Caribbean octocorals demonstrate bioactivity against Vibrio coralliilyticus strains ." Coral Reefs , https://doi.org/10.1007/s00338-024-02516-6 .
2024
Ushijima, Blake, Gunasekera, Sarath P., Meyer, Julie L., Paul, Valerie J., Tittl, Jessica, Pitts, Kelly A., Thompson, Sharon, Sneed, Jennifer M., Ding, Yousong, Chen, Manyun, Jay Houk, L., Aeby, Greta S., and Häse, Claudia C. 2023. "Chemical and genomic characterization of a potential probiotic treatment for stony coral tissue loss disease ." Communications Biology , 6, (1). https://doi.org/10.1038/s42003-023-04590-y .
2023
Meyer, Julie L., Gunasekera, Sarath P., Brown, Anya L., Ding, Yousong, Miller, Stephanie, Teplitski, Max, and Paul, Valerie J. 2023. "Cryptic Diversity of Black Band Disease Cyanobacteria in Siderastrea siderea Corals Revealed by Chemical Ecology and Comparative Genome-Resolved Metagenomics ." Marine Drugs , 21, (2). https://doi.org/10.3390/md21020076 .
2023
Gunasekera, Sarath P., Kokkaliari, Sofia, Ratnayake, Ranjala, Sauvage, Thomas, dos Santos, Larissa A. H., Luesch, Hendrik, and Paul, Valerie J. 2022. "Anti-Inflammatory Dysidazirine Carboxylic Acid from the Marine Cyanobacterium Caldora sp. Collected from the Reefs of Fort Lauderdale, Florida ." Molecules , 27, (5). https://doi.org/10.3390/molecules27051717 .
2022
Brumley, David A., Gunasekera, Sarath P., Sauvage, Thomas, dos Santos, Larissa A. H., Chen, Qi-Yin, Paul, Valerie J., and Luesch, Hendrik. 2022. "Discovery, Synthesis, and Biological Evaluation of Anaenamides C and D from a New Marine Cyanobacterium, Hormoscilla sp br." Journal of natural products , 85, (3) 581–589. https://doi.org/10.1021/acs.jnatprod.1c01073 .
2022
Brumley, David A., Gunasekera, Sarath P., Chen, Qi-Yin, Paul, Valerie J., and Luesch, Hendrik. 2020. "Discovery, Total Synthesis, and SAR of Anaenamides A and B: Anticancer Cyanobacterial Depsipeptides with a Chlorinated Pharmacophore ." Organic letters , 22, (11) 4235–4239. https://doi.org/10.1021/acs.orglett.0c01281 .
2020
Ratnayake, Ranjala, Gunasekera, Sarath P., Ma, Jia Jia, Dang, Long H., Carney, Thomas, Paul, Valerie J., and Luesch, Hendrik. 2020. "Dolastatin 15 from a Marine Cyanobacterium Suppresses HIF-1α Mediated Cancer Cell Viability and Vascularization ." Chembiochem: A European Journal of Chemical Biology , 21, (16) 2356–2366. https://doi.org/10.1002/cbic.202000180 .
2020
Lydon, Christina A., Mathivathanan, Logesh, Sanchez, Juanita, dos Santos, Larissa A. H., Sauvage, Thomas, Gunasekera, Sarath P., Paul, Valerie J., and Berry, John P. 2020. "Eudesmacarbonate, a Eudesmane-Type Sesquiterpene from a Marine Filamentous Cyanobacterial Mat (Oscillatoriales) in the Florida Keys ." Journal of natural products , 83, (6) 2030–2035. https://doi.org/10.1021/acs.jnatprod.0c00203 .
2020
Gunasekera, Sarath P., Meyer, Julie L., Ding, Yousong, Abboud, Khalil A., Luo, Danmeng, Campbell, Justin E., Angerhofer, Alexander, Goodsell, Justin L., Raymundo, Laurie J., Liu, Junyang, Ye, Tao, Luesch, Hendrik, Teplitski, Max, and Paul, Valerie J. 2019. "Chemical and Metagenomic Studies of the Lethal Black Band Disease of Corals Reveal Two Broadly Distributed, Redox-Sensitive Mixed Polyketide/Peptide Macrocycles ." Journal of natural products , 82, (1) 111–121. https://doi.org/10.1021/acs.jnatprod.8b00804 .
2019
Liang, Xiao, Luo, Danmeng, Yan, Jia-Lei, Rezaei, Mohammad A., Salvador-Reyes, Lilibeth, Gunasekera, Sarath P., Li, Chenglong, Ye, Tao, Paul, Valerie J., and Luesch, Hendrik. 2019. "Discovery of Amantamide, a Selective CXCR7 Agonist from Marine Cyanobacteria ." Organic letters , 21, (6) 1622–1626. https://doi.org/10.1021/acs.orglett.9b00163 .
2019
Brumley, David, Spencer, Kara A., Gunasekera, Sarath P., Sauvage, Thomas, Biggs, Jason, Paul, Valerie J., and Luesch, Hendrik. 2018. "Isolation and Characterization of Anaephenes A–C, Alkylphenols from a Filamentous Cyanobacterium ( Hormoscilla sp., Oscillatoriales) ." Journal of natural products , 81, (12) 2716–2721. https://doi.org/10.1021/acs.jnatprod.8b00650 .
2018
Sneed, Jennifer M., Meickle, Theresa, Engene, Niclas, Reed, Sherry, Gunasekera, Sarath, and Paul, Valerie J. 2017. "Bloom dynamics and chemical defenses of benthic cyanobacteria in the Indian River Lagoon, Florida ." Harmful Algae , 69, (Supplement C) 75–82. https://doi.org/10.1016/j.hal.2017.10.002 .
2017
Cox, Clayton E., Brandl, Maria T., de Moraes, Marcos H., Gunasekera, Sarath, and Teplitski, Max. 2017. "Production of the Plant Hormone Auxin by Salmonella and Its Role in the Interactions with Plants and Animals ." Frontiers in Microbiology , 8 2668. https://doi.org/10.3389/fmicb.2017.02668 .
2017
Gunasekera, Sarath P., Imperial, Lorelie, Garst, Christiana, Ratnayake, Ranjala, Dang, Long H., Paul, Valerie J., and Luesch, Hendrik. 2016. "Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata ." Journal of natural products , 79, (7) 1867–1871. https://doi.org/10.1021/acs.jnatprod.6b00203 .
2016
Gunasekera, Sarath P., Li, Yang, Ratnayake, Ranjala, Luo, Danmeng, Lo, Jeannette, Reibenspies, Joseph H., Xu, Zhengshuang, Clare-Salzler, Michael, Ye, Tao, Paul, Valerie J., and Luesch, Hendrik. 2016. "Discovery, Total Synthesis and Key Structural Elements for the Immunosuppressive Activity of Cocosolide, a Symmetrical Glycosylated Macrolide Dimer from Marine Cyanobacteria ." Chemistry - A European Journal , 22, (24) 8158–8166. https://doi.org/10.1002/chem.201600674 .
2016
Meyer, Julie L., Gunasekera, Sarath P., Scott, Raymond M., Paul, Valerie J., and Teplitski, Max. 2016. "Microbiome shifts and the inhibition of quorum sensing by Black Band Disease cyanobacteria ." The ISME journal , 10 1204–1216. https://doi.org/10.1038/ismej.2015.184 .
2016
Soares, Angélica R., Engene, Niclas, Gunasekera, Sarath P., Sneed, Jennifer M., and Paul, Valerie J. 2015. "Carriebowlinol, an Antimicrobial Tetrahydroquinolinol from an Assemblage of Marine Cyanobacteria Containing a Novel Taxon." Journal of natural products , 78, (3) 534–538. https://doi.org/10.1021/np500598x .
2015
Hagedorn, Mary M., Farrell, Ann, Carter, Virginia, Zuchowicz, Nikolas, Johnston, Erika, Padilla-Gamiño, Jacqueline, Gunasekera, Sarath, and Paul, Valerie J. 2015. "Effects of Toxic Compounds in Montipora capitata on Exogenous and Endogenous Zooxanthellae Performance and Fertilization Success ." PloS One , 10, (2) 1–17. https://doi.org/10.1371/journal.pone.0118364 .
2015
Engene, Niclas, Gunasekera, Sarath, Gerwick, William H., and Paul, Valerie J. 2013. "Phylogenetic Inferences Reveal Large Extent of Novel Biodiversity in Chemically Rich Tropical Marine Cyanobacteria ." Applied and Environmental Microbiology , 79, (6) 1882–1888. https://doi.org/10.1128/AEM.03793-12 .
2013
Abed, Raeid M. M., Dobretsov, Sergey, Al-Fori, Marwan, Gunasekera, Sarath P., Sudesh, Kumar, and Paul, Valerie J. 2013. "Quorum-sensing inhibitory compounds from extremophilic microorganisms isolated from a hypersaline cyanobacterial mat ." Journal of industrial microbiology & biotechnology , 40, (7) 759–772. https://doi.org/10.1007/s10295-013-1276-4 .
2013
Dobretsov, Sergey, Teplitski, Max, Bayer, Mirko, Gunasekera, Sarath, Proksch, Peter, and Paul, Valerie J. 2011. "Inhibition of marine biofouling by bacterial quorum sensing inhibitors ." Biofouling , 27, (8) 893–905. https://doi.org/10.1080/08927014.2011.609616 .
2011
Gunasekera, Sarath P., Owle, Chivas S., Montaser, Rana, Luesch, Hendrik, and Paul, Valerie J. 2011. "Malyngamide 3 and cocosamides A and B from the marine cyanobacterium Lyngbya majuscula from Cocos Lagoon, Guam ." Journal of natural products , 74, (4) 871–876. https://doi.org/10.1021/np1008015 .
2011
Meickle, Theresa, Gunasekera, Sarath P., Liu, Yanxia, Luesch, Hendrik, and Paul, Valerie J. 2011. "Porpoisamides A and B, two novel epimeric cyclic depsipeptides from a Florida Keys collection of Lyngbya sp." Bioorganic & medicinal chemistry , 19, (22) 6576–6580. https://doi.org/10.1016/j.bmc.2011.05.051 .
2011
Kwan, Jason C., Teplitski, Max, Gunasekera, Sarath, Paul, Valerie J., and Luesch, Hendrik. 2010. "Isolation and Biological Evaluation of 8-epi-Malyngamide C from the Floridian Marine Cyanobacterium Lyngbya majuscula† ." Journal of natural products , 73, (3) 463–466. https://doi.org/10.1021/np900614n .
2010
Dobretsov, Sergey, Teplitski, Max, Alagely, Ali, Gunasekera, Sarath, and Paul, Valerie J. 2010. "Malyngolide from the cyanobacterium Lyngbya majuscula interferes with quorum sensing circuitry ." Environmental Microbiology Reports , 2, (6) 739–744. https://doi.org/10.1111/j.1758-2229.2010.00169.x .
2010
Gunasekera, Sarath, Miller, Margaret W., Kwan, Jason C., Luesch, Hendrik, and Paul, Valerie J. 2010. "Molassamide, a Depsipeptide Serine Protease Inhibitor from the Marine Cyanobacterium Dichothrix utahensis† ." Journal of natural products , 73, (3) 459–462. https://doi.org/10.1021/np900603f .
2010
Sharp, Koty, Arthur, Karen E., Gu, Liangcai, Ross, Cliff, Harrison, Genelle, Gunasekera, Sarath, Meickle, Theresa, Matthew, Susan, Luesch, Hendrik, Thacker, Robert W., Sherman, David H., and Paul, Valerie J. 2009. "Phylogenetic and Chemical Diversity of Three Chemotypes of Bloom-Forming Lyngbya Species (Cyanobacteria: Oscillatoriales) from Reefs of Southeastern Florida ." Applied and Environmental Microbiology , 75, (9) 2879–2888. https://doi.org/10.1128/AEM.02656-08 .
2009
Gunasekera, Sarath, Ritson-Williams, Raphael, and Paul, Valerie J. 2008. "Carriebowmide, a New Cyclodepsipeptide from the Marine Cyanobacterium Lyngbya polychroa." Journal of Natural Products , 71, (12) 2060–2063. https://doi.org/10.1021/np800453t .
2008
Gunasekera, Sarath, Ross, C., Paul, Valerie J., Matthew, S., and Luesch, Hendrik. 2008. "Dragonamides C and D, linear lipopeptides from the marine cyanobacterium brown Lyngbya polychroa ." Journal of Natural Products , 71, (5) 887–890. https://doi.org/10.1021/np0706769 .
2008