We present a wide-field study of the globular cluster (GC)/low-mass X-ray binary (LMXB) connection in the giant elliptical NGC 1399. The large field of view of the Advanced Camera for Surveys/WFC, combined with Hubble Space Telescope and Chandra high resolution, allow us to constrain the LMXB formation scenarios in elliptical galaxies. We confirm that NGC 1399 has the highest LMXB fraction in GCs of all nearby elliptical galaxies studied so far, even though the exact value depends